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Cartoon illustrating the structure of the solid-state tetramer of macrocyclic β-sheet 1 (top), and the solution-state tetramer of macrocyclic β-sheets 1 and 2a (bottom). The VF faces form the inner hydrophobic core of the solid-state tetramer of 1, and the LFA faces form the outer surface. The LFA faces form the inner hydrophobic core of the solution-state tetramer of 1 and 2a, and the VF faces form the outer surface.
