Table 1. Diffusion Coefficients (D) of Peptides 1–4 in D2O at 298 K.
peptide | MWmonomera (Da) | MWtetramera (Da) | D (10–7 cm2/s) | oligomer state |
---|---|---|---|---|
1 | 2232 | 8929 | 10.1b | tetramer |
2a | 2169 | 8677 | 10.0b | tetramer |
10.1c | ||||
2b | 2187 | 8749 | 10.3b | tetramer |
10.1c | ||||
2c | 2201 | NA | 16.5b | monomer |
3 | 2196 | 8785 | 16.4b | monomer |
4 | 2183 | NA | 17.6b | monomer |
Molecular weight calculated for the neutral (uncharged) macrocycle.
Diffusion coefficient measured at 2.0 mM.
Diffusion coefficient measured at 8.0 mM.