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. 2014 Feb 27;8(3):1995–2017. doi: 10.1021/nn5004277

Figure 3.

Figure 3

Size-based filtration techniques. (a) Melanoma cells preincubated with immunobeads captured on a nylon monofilament filter.32 Adapted with permission from ref (32). Copyright 1997 Elsevier. (b) Culture of captured melanoma cells on nylon monofilament filter.32 Adapted with permission from ref (32). Copyright 1997 Elsevier. (c) Stained cells as separated using the polycarbonate filter found in ISET (Isolation by Size of Epithelial Tumor Cells) technology [1, spiked tumor cells; 2, membrane pores; 3, leukocytes].33 Adapted with permission from ref (33). Copyright 2000 Elsevier. (d) Parylene C microfilter released from silicon mold.36 Adapted with permission from ref (36). Copyright 2007 Elsevier. (e) Two-layer microfilter to protect cells from damaging forces.38 Adapted with permission from ref (38). Copyright 2010 Springer Science+Business Media, LLC. (f) CTC clusters isolated by RIA (reversible bead attachment for cell isolation and analysis) and different levels of HER2 expression in CTCs isolated from metastatic breast cancer patients.39 Adapted with permission from ref (39). Copyright 2007 John Wiley & Sons, Inc.