Table 4.
Combinations of categories of alcohol consumption and cigarette smoking and risk (multivariablea adjusted incidence RRs) of subtypes of head-neck cancer; Netherlands Cohort Study (NLCS), 1986 - 2003
| |
Head-neck cancer cases |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| |
Overall |
Subtypes |
|
|
|
|
|
||||
| |
|
|
|
|
|
OCC
b
|
OHPC
b
|
LC
b
|
|||
| |
Alcohol consumption (grams ethanol/day) |
Alcohol consumption
c
|
Alcohol consumption
c
|
Alcohol consumption
c
|
|||||||
| 0 | >0 to <5 | 5 to <15 | 15 to <30 | ≥30 | 0-15 | >15 | 0-15 | >15 | 0-15 | >15 | |
|
Frequency of cigarette smoking (
N
/day) | |||||||||||
|
Never smokers |
|
|
|
|
|
|
|
|
|
|
|
| Cases/person time at riskd |
10/8959 |
13/9729 |
7/4245 |
11/1499 |
3/619 |
21/22933 |
8/2118 |
3/22933 |
3/2118 |
6/22933 |
3/2118 |
| RR |
1 (ref) |
1.20 |
1.23 |
5.53 |
2.97 |
1 (ref) |
4.16 |
1 (ref) |
10.18 |
1 (ref) |
3.05 |
| 95% CI |
|
0.52 – 2.75 |
0.46 – 3.29 |
2.27 – 13.49 |
0.78 – 11.40 |
|
1.82 – 9.52 |
|
2.03 – 51.06 |
|
0.72 – 12.92 |
|
>0 to <20 |
|
|
|
|
|
|
|
|
|
|
|
| Cases/person time at risk |
21/4194 |
25/6534 |
37/7061 |
40/4814 |
32/2184 |
20/17789 |
18/6998 |
18/17789 |
12/6998 |
44/17789 |
41/6998 |
| RR |
1.89 |
1.56 |
2.04 |
2.63 |
3.81 |
0.76 |
1.55 |
4.02 |
5.63 |
2.66 |
4.19 |
| 95% CI |
0.83 – 4.34 |
0.71 – 3.41 |
0.95 – 4.40 |
1.22 – 5.67 |
1.71 – 8.51 |
0.34 – 1.71 |
0.66 – 3.62 |
1.07 – 15.14 |
1.44 – 22.00 |
1.03 – 6.86 |
1.60 – 11.02 |
|
≥20 |
|
|
|
|
|
|
|
|
|
|
|
| Cases/person time at risk |
18/2102 |
29/2745 |
28/3162 |
41/3648 |
80/2856 |
7/8010 |
36/6504 |
16/8010 |
31/6504 |
52/8010 |
53/6504 |
| RR |
2.78 |
3.88 |
2.85 |
3.32 |
8.28 |
0.58 |
3.54 |
7.26 |
16.12 |
5.42 |
5.54 |
| 95% CI |
1.18 – 6.54 |
1.77 – 8.49 |
1.28 – 6.34 |
1.52 – 7.25 |
3.98 – 17.22 |
0.21 – 1.58 |
1.66 – 7.52 |
1.86 – 28.44 |
4.31 – 60.27 |
2.10 – 13.98 |
2.15 – 14.27 |
| P for interactione | 0.03 | 0.10 | 0.09 | 0.19 | |||||||
aAdjusted for age, sex, current cigarette smoking, and duration of cigarette smoking (years; continuous; centered).
bOCC: oral cavity cancer; OHPC: oro-/hypopharyngeal cancer; LC: laryngeal cancer.
cFor the categorical interaction analyses in HNC-subtypes, it was necessary to aggregate categories of alcohol consumption (grams ethanol/day) in order to obtain sufficient numbers in strata.
dPerson time at risk in years.
eP Value for interaction between categories of alcohol consumption and cigarette smoking, based on cross-product terms in the Cox proportional hazards model and Wald test.