Figure 3. Noradrenaline-induced vasoconstriction in mesenteric resistance arteries from SHR is attenuated by anti-TLR4 treatment.
Maximal response to (A) noradrenaline in mesenteric resistance arteries from Wistar and SHR treated with IgG (white bars) or anti-TLR4 (black bars). Cumulative concentration-response curves to noradrenaline in endothelium-intact mesenteric resistance arteries from (B) Wistar treated with IgG (open circle) or anti-TLR4 (closed circle), and (C) SHR treated with IgG (open square) or anti-TLR4 (closed square). Each point represents the mean ± SEM of maximal response to each concentration, n = 10-12. *P < 0.05 compared with Wistar IgG and # P < 0.05 compared with SHR IgG. Statistical test: one-way ANOVA.