. Author manuscript; available in PMC: 2014 Apr 29.

Published in final edited form as: Clin Sci (Lond). 2012 Jun;122(11):535–543. doi: 10.1042/CS20110523

Table 1.

Maximal response (E_MAX) and sensitivity (pD₂) to noradrenaline (NA) with or without inhibitors in mesenteric resistance arteries from Wistar and SHR treated with IgG or anti-TLR4.

	Wistar IgG		Wistar anti-TLR4		SHR IgG		SHR anti-TLR4

	E_MAX	pD₂	E_MAX	pD₂	E_MAX	pD₂	E_MAX	pD₂
NA	19.9±1.4	6.3±0.06	17.1±1.9	6.1±0.08	27.8 ± 1.6^†	6.1 ± 0.04	19.0± 1.7^*	5.8 ± 0.08^*
NA + NS-398	14.2±1.9	6.0±0.07	14.9±1.7	5.9±0.06	17.1 ± 1.3^*	5.2 ± 0.05^*	15.8 ± 1.1	5.5 ± 0.06
NA + SC-560	21.3±3.7	6.1±0.08	19.5±1.9	6.3±0.07	15.9 ± 1.1^*	5.3 ± 0.04^*	18.9 ± 1.5	5.5 ± 0.03

Values are means ± SEM. n = 6-12.

P < 0.05 vs. SHR IgG (NA);

^†

P < 0.05 compared with Wistar IgG (NA).

NS-398: Cox-2 inhibitor: SC-560: Cox-1 inhibitor, E_MAX: maximal response; pD₂: -log EC50. Statistical test: one-way ANOVA