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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: IUBMB Life. 2013 Sep 17;65(10):819–826. doi: 10.1002/iub.1204

Figure 2. eNOS-derived NO signaling pathways.

Figure 2

The classical cGMP-dependent pathway is illustrated on the left hand side (sGC: soluble guanylyl cyclase; cGMP: cyclic guanylyl monophosphate; PKG: protein kinase G; ERK 1/2: extracellular regulated kinase 1-2). The regulatory phosphodiesterases (PDE's) and phosphatases (PPases) are also illustrated. The cGMP-indpendent S-nitrosation pathway is shown on the right side. The denitrosating agents thioredoxin (Trx), thioredoxin reductase (TrxR); glutathione (GSH) and S-Nitrosoglutathione Reductase (GSNOR) are depicted as control for the process. Both pathways are regulated through the exquisite mechanisms that control eNOS. Both pathways appear to converge at some point(s) that modulates the adherens junctional protein complex.