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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Genes Immun. 2013 Nov 7;15(1):38–46. doi: 10.1038/gene.2013.59

Figure 6.

Figure 6

CD23 Mean Fluorescence Intensity in the Founder Strains and F1 crosses. A) B-cell subsets as defined by CD21 and CD23 in the B6 (gray) and PWK (red). Note that there is very little difference in CD21 expression between the two strains, while CD23 in the PWK is extremely reduced if not absent. B) CD23 surface expression in the founder strains. All MFI measurements are normalized to the B6 control in each experiment. Males and females are pooled. Note low CD23 levels in 129S1, CAST, and PWK. C) ELISA for serum IgE. Pooled sera were obtained from 8-12 week old males from each of the founder strains. Pooled serum from the 129X1 was also included as a positive control for high IgE. Error bars reflect assay precision. D) Inheritance of CD23 MFI in F1 crosses of the B6 with 129S1, CAST, and PWK. Reciprocal crosses, males and females are all pooled. E) Zoomed in region of genome scan for CD23 MFI indicating location of Fcer2a, confidence intervals, and genomewide significance threshold. F) Estimated strain effects for CD23MFI (log base 10 scale) at the Fcer2a locus.