Table 1.
Summary of immune phenotypes and their variation among the founders. INT: inverse normal transformation; logit: is the logit function; log10: log to the base 10.
| Phenotype | Description | Measurement | Transformation for statistical analysis | ANOVA of strain effect | Number of mice per strain (129, AJ, B6, CAST, NOD, NZO, PWK, WSB, B6 controls) | |
|---|---|---|---|---|---|---|
| F statistic | P-Value | |||||
| -APCs | Total Lymphoid Cells | % of Total Cells | Logit | F7,38=4.28 | 0.00144 | 6, 6, 10, 2, 6, 10, 9, 10, 62 |
| +APCs | Total Myeloid Cells | % of Total Cells | Logit | F7,48=15.1 | 3.23E-10 | 6, 6, 10, 2, 6, 10, 9, 10, 62 |
| B/T | Ratio of B-cells to T-cells | CD19+ / H57+ | Log10 | F7,38=10.4 | 3.44E-05 | 6, 6, 10, 2, 6, 10, 9, 10, 62 |
| CD11b Hi | Phagocytes | % of Total Cells | Logit | F7,38=3.89 | 0.00275 | 6, 6, 10, 2, 6, 10, 9, 10, 61 |
| CD11b MFI | CD11b Antigen Density on Dendritic Cells | Mean Fluorescence Intensity (MFI) | Log10 | F7,38=5.39 | 2.40E-04 | 6, 6, 10, 2, 6, 10, 9, 10, 61 |
| CD11c MFI | CD11c Antigen Density on Dendritic Cells | MFI | Log10 | F7,38=22.4 | 1.13E-11 | 6, 6, 10, 2, 6, 10, 9, 10, 61 |
| CD11c+ | CD11c+/CD11b-Dendritic Cells | % of Total Cells | Logit | F7,38=2.01 | 0.0785 | 6, 6, 10, 2, 6, 10, 9, 10, 61 |
| CD19+ | Total B-cells | % of Total Cells | Logit | F7,38=4.14 | 1.79E-03 | 6, 6, 10, 2, 6, 10, 9, 10, 62 |
| CD23 MFI | CD23 antigen density on all B-cells | MFI | Log10 | F7,38=14.3 | 6.10E-09 | 6, 6, 10, 2, 6, 10, 9, 10, 62 |
| CD4+ | Helper and Regulatory T-cells | % of H57+ | Logit | F7,38=8.87 | 1.96E-06 | 6, 6, 10, 2, 6, 10, 9, 10, 62 |
| CD4+, CD25+ | Regulatory T-cells | % of CD4+ | Logit | F7,38=7.75 | 8.15E-06 | 6, 6, 10, 2, 6, 10, 9, 10, 58 |
| CD4+/CD8+ | Ratio of Helper T-cells to Cytotoxic T-cells | CD4+ / CD8+ | Log10 | F7,38=6.45 | 4.91E-05 | 6, 6, 10, 2, 6, 10, 9, 10, 62 |
| CD8+ | Cytotoxic T-cells | % of H57+ | Logit | F7,38=5.38 | 2.42E-04 | 6, 6, 10, 2, 6, 10, 9, 10, 62 |
| DCs | Classical Dendritic Cells | % of Total Cells | Logit | F7,38=16.1 | 1.31E-09 | 6, 6, 10, 2, 6, 10, 9, 10, 61 |
| FoB | Follicular B-cells | % of CD19+ | INT | F7,38=9.63 | 7.88E-07 | 6, 6, 10, 2, 6, 10, 9, 10, 58 |
| Granulocytes | Granulocytes | % of Total Cells | Logit | F7,38=2.41 | 0.0381 | 6, 6, 10, 2, 6, 10, 9, 10, 61 |
| H57+ | Total T-cells | % of Total Cells | Logit | F7,48=5.52 | 1.95E-04 | 6, 6, 10, 2, 6, 10, 9, 10, 62 |
| Macrophages | Macrophages | % of Total Cells | Logit | F7,38=6.49 | 4.63E-05 | 6, 6, 10, 2, 6, 10, 9, 10, 61 |
| Monocytes | Monocytes | % of Total Cells | Logit | F7,38=11 | 1.60E-07 | 6, 6, 10, 2, 6, 10, 9, 10, 61 |
| MZB | Marginal Zone B-cells | % of CD19+ | INT | F7,38=18.1 | 2.56E-10 | 6, 6, 10, 2, 6, 10, 9, 10, 58 |
| TransB | Transitional B-cells | % of CD19+ | INT | F7,38=6.52 | 4.45E-05 | 6, 6, 10, 2, 6, 10, 9, 10, 58 |