Table 3.

Coding polymorphisms in the gene Fcer2a. Conservation score ranges from 1 (highly conserved amino acid substitutions) to 0 (nonconserved). Merge scores rate the ability of the polymorphism to explain the association between CD23 MFI and the haplotypes at the Fcer2a locus, with positive scores indicating better support. The last column measures the strength of association (LogP) at the chr 8 QTL peak (originally 9.58) after controlling for potential effects of the Fcer2a polymorphism (see Methods and Results for details).

A.A.#	Human	A/J	B6	129S1	NOD	NZO	CAST	PWK	WSB	Protein Region	Conservation among founders (inc. human)	Merge Score	Conditional LogP at QTL peak
82	A	A	A	T	A	A	A	A	A	Stalk	0.809 (0.847)	-1.83	2.55
87	S	V	V	A	V	V	A	A	V	Stalk	0.648 (0.540)	5.49	1.91
117	G	G	G	G	G	G	E	E	G	Stalk	0.648 (0.731)	-27.25	7.08
131	-	K	K	E	K	E	E	E	E	Stalk	0.673 (0.439)	-22.22	6.37
258	V	S	S	L	S	S	L	L	S	Lectin	0.531 (0.475)	4.66	1.91
301	G	D	D	N	D	D	N	D	D	Lectin	0.710 (0.599)	-3.73	3.20