TABLE 1.

Comparison of Features of Cerebrovascular versus Parenchymal Senile Plaque Amyloid Deposition

Feature	Cerebrovascular Amyloid Deposition	Senile Plaque Amyloid Deposition
Predominant Aβ type	Aβ40	Aβ42 (particularly in diffuse plaques)
Location of Aβ deposition	Relative occipital lobe predominance	Frontal, parietal, temporal lobes
APOE allele risk factors	APOE ε4 (for amyloid deposition) and APOE ε2 (for vessel breakdown)	APOE ε4
Inflammatory subtype with reversible white matter hyperintensities	Occurs spontaneously as CAA-related inflammation	May occur iatrogenically as a result of amyloid immunotherapy or other candidate treatments targeting amyloid
Cerebral microbleeds	Lobar predominant, particularly occipital	Not associated with senile plaques
Location of white matter disease	Equal distribution between anterior and posterior subcortical regions (subgroup may have posterior-dominant white matter disease)	Equal distribution between anterior and posterior subcortical regions, but less extensive than advanced CAA

See text for more details discussion and details.

APOE = apolipoprotein E; CAA = cerebral amyloid angiopathy.