Table 1.
DNA oligo entrapment [a] | 111In entrapment [b] | Average size/PDI [c] | Zeta potential [c] (outer leaflet DOPC/Cholesterol + 20% DSPE-PEG) | Calcium/Phosph ate ratio of the LCP core [d] | |
---|---|---|---|---|---|
S-LCP | 64.4 ± 4.4% | 30.7 ± 4.1 % | 25.3 ± 1.9 nm/0.3 | −19.9 ± 4.1 mV | 1.01 ± 0.04 |
L-LCP | 29.2 ± 0.5% | 32.3 ± 2.2 % | 67.2 ± 2.0 nm/0.4 | −18.0 ± 2.0 mV | 0.89 ± 0.03 |
determined by tritium labeled DNA oligo and liquid scintillation counting (N=3)
determined by 111In gamma counting (N=4)
measured by dynamic light scattering (N=3)
analyzed by inductively coupled plasma mass spectrometry. (N=3)