Resonance assignment of GB1 with random and independent deletion of 20% of the peaks, which do not come from the same residues between the NCACX (a, c, e) and NCOCX (b, d, f) datasets. (a, b) MC/SA found 56 valid results, among which 43 are distinct. 4 residues are “mis-assigned” for each dataset. Various residues have low probabilities for the top assignment, some of which are nevertheless correct. (c, d) Modified NSGA-II found 54 Parato-frontier solutions with 2 and 1 “mis-assignments”. (e, f) The combination algorithm found 80 Paratoorder- 1 solutions with 1 and 2 “mis-assignments”.