Resonance assignment of HNP-1. (a, c, e) NCACX data. (b, d, f) NCOCX data. (a, b) MC/SA found 100 valid assignments containing 52 distinct solutions. (c, d) Modified NSGA-II found 100 Pareto-order-1 results. (e, f) Combination NSGA-II/MC produced 84 Pareto-order-1 results. All three methods show ambiguous predictions, but more residues are correctly predicted with high (>90%) probabilities by NSGA-II and the combination algorithm than by MC/SA.