Figure 3.

The change in the required dose of antibody for increasing levels of target binding protein depends on whether the antibody competes or not for the target with the binding protein. Using the base-case parameters from example 1, a subcutaneous dose of 100 mg of the antibody of either mechanism is required to maintain 90% suppression of the target when levels of a binding protein for the target arenegligibly low. The required dose changes as levels of this binding protein increase: the dose decreases for an antibody that also binds the target and binding protein complex but increases for an antibody that competes with the binding protein. , competitive; , non-competitive