Table 2.
Pharmacokinetic parameters in final population model
| Parameter description | Population estimate (%SEE) | Inter-patient variability (%SEE) |
|---|---|---|
| Rate of absorption | ||
| Parameter for Ka (h−1) | 2.24 (20) | 76 (36) |
| Clearance | ||
| Parameter for CL/F (l h−1) | 38.4 (8.4) | 46 (36) |
| Volume of distribution for first compartment | ||
| Parameter for V1/F (l) | 100 (10) | 42 (34) |
| Volume of distribution for second compartment | ||
| Parameter for V2/F (l) | 92.8 (12) | 48 (33) |
| Inter-compartment clearance | ||
| Parameter for Q (l h−1) | 9.2 (13) | 40 (57) |
| Between-occasion variability CL_IOV | 18 (65) | |
| Residual error (additive) | 0.15 (20) | |
| Residual error (proportional) | 51 (10) |
CL/F, apparent clearance; Ka, absorption rate constant; SEE, standard error of the estimate; V/F, apparent volume of distribution.