Table 5.
Summary of absolute bioavailability (%) of fluticasone furoate following inhaled administration and statistical analysis results
| Treatment | Ethnic group | Geometric mean (95% CI) | Comparison | Ratio of adjusted geometric mean | 90% CI of ratio | |
|---|---|---|---|---|---|---|
| FF 200 μg | Caucasian | 8 | 19.2 (14.6, 25.3) | Chinese : Caucasian | 1.279 | (0.953, 1.716) |
| Day 7 | Chinese | 17 | 20.0 (16.6, 24.0) | Japanese : Caucasian | 1.243 | (0.918, 1.685) |
| Japanese | 14 | 19.2 (15.4, 24.0) | Korean : Caucasian | 1.306 | (0.974, 1.753) | |
| Korean | 18 | 18.8 (16.7, 21.1) | ||||
| FF 800 μg | Caucasian | 11 | 11.2 (7.70, 16.3) | Chinese : Caucasian | 1.356 | (1.026, 1.791) |
| Day 1 | Chinese | 19 | 14.1 (9.70, 20.4) | Japanese : Caucasian | 1.887 | (1.417, 2.513) |
| Japanese | 17 | 19.7 (15.1, 25.7) | Korean : Caucasian | 1.421 | (1.074, 1.881) | |
| Korean | 19 | 15.0 (13.5, 16.7) | ||||
| FF 800 μg | Caucasian | 16 | 10.4 (8.10, 13.4) | Chinese : Caucasian | 1.364 | (1.045, 1.779) |
| Day 8 | Chinese | 19 | 14.3 (11.3, 18.1) | Japanese : Caucasian | 1.551 | (1.180, 2.039) |
| Japanese | 18 | 16.3 (12.5, 21.3) | Korean : Caucasian | 1.469 | (1.124, 1.920) | |
| Korean | 19 | 15.4 (13.5, 17.6) |
CI, confidence interval; FF, fluticasone furoate.