Table 6.
Summary of fluticasone furoate absorption pharmacokinetic parameters following inhaled administration of 800 μg single dose
| Parameter (units) | Caucasian subjects n = 19 | Chinese subjects n = 20 | Japanese subjects n = 20 | Korean subjects n = 20 | ||||
|---|---|---|---|---|---|---|---|---|
| n | Geometric mean (95% CI) | n | Geometric mean (95% CI) | n | Geometric mean (95% CI) | n | Geometric mean (95% CI) | |
| MAT (h) | 18 | 5.15(2.84, 9.32) |
20 | 10.6(8.72, 12.8) |
19 | 9.67(7.78, 12.0) |
20 | 10.6(9.41, 11.9) |
| t90 (h) | 18 | 21.4(16.3, 28.1) |
20 | 29.9(23.7, 37.8) |
18 | 29.1(25.2, 33.6) |
20 | 30.8(28.8, 32.9) |
| t1/2,abs (h) | 18 | 8.05(6.02, 10.8) |
20 | 9.21(7.21, 11.7) |
18 | 9.91(8.29, 11.8) |
20 | 10.2(9.44, 10.9) |
CI, confidence interval; MAT, mean absorption time; t1/2, abs, absorption half-life; t90, time for 90% to be absorbed.