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. 2014 Apr 29;9(4):e96161. doi: 10.1371/journal.pone.0096161

Figure 3. Effects of BM-MSC-derived conditioned medium samples on paracrine cell proliferation and migration.

Figure 3

Equal numbers of keratinocytes, fibroblasts and HUVECs were incubated with vehicle control medium, norCM or hypoCM. Cell proliferation was evaluated at indicated time points (A, C and E). Data are given as the means±the SEM; *p< 0.05 compared with the vehicle control or the norCM group. #p< 0.05 the vehicle control compared with the norCM group. Equal numbers of keratinocytes, fibroblasts, HUVECs and CD14+ monocytes were added to the upper chambers of 24-well transwell plates, with the indicated medium added to the lower chambers (n = 4 wells per treatment). Cells that migrated to the bottom of the filter were stained and evaluated (B, D, F and G). Data are given as the means± the SEM;*p< 0.05 compared with the vehicle control or the norCM group. #p< 0.05 the vehicle control compared with the norCM group.