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. 2014 May 1;25(9):1458–1471. doi: 10.1091/mbc.E13-04-0215

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© 2014 Ma, Miller, et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — RhoGEFs encoded by the Mus musculus genome with putative Sec14 and spectrin repeat domains. The N-terminal region of each protein is drawn approximately to scale. (A) Major isoforms of mouse Kalrn. The presence of nine spectrin repeats (SRs) was experimentally verified (Vishwanatha et al., 2012). The longer isoforms (Kal8, Kal9, Kal12) contain additional domains (SH3, GEF2, kinase). (B) The N-terminal region of a single splice variant of Trio and the Kalrn/Trio orthologue in C. elegans and Drosophila melanogaster is shown with predicted SRs. (C) A single splice variant of each additional M. musculus RhoGEF with a predicted Sec14 domain is shown. Sec14, CRAL_TRIO domain, green oval; SR, spectrin-like repeat, yellow parallelogram; DH, Dbl homology domain, blue polygon; PH, pleckstrin homology domain, purple triangle; SH, Src homology 3 domain, pink rectangle; PDZ-binding motif, red bar. Kalrn, A2CG49; Trio, Q0KL02; Drosophila trio A, Q7KVD1; unc-73A, O61528; Mcf2, A2AEU1; Mcf2l, Q64096; Puratrophin-1 (Plekhg4), mFLJ00068.