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. 2014 May 1;25(9):1523–1531. doi: 10.1091/mbc.E13-10-0590

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© 2014 Ishaq et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 7: — Model for the regulation of TNF-receptor–mediated apoptosis pathway induced by AGP. The induced production of ROS and TNF pathway activation by cross-talk (direct or indirect interaction), which leads to activation of ASK1 and stimulation of downstream p38α MAPK or JNK to induce caspase-3/7–dependent cancer cell apoptosis.