Fig. 2.

(a) Macroscopy of the extracted orbital tumor: highly pigmented 6×2 cm large tumor, which ruptured during the extirpation. (b) Hematoxylin and eosin staining of the orbital tumor (×20): melanin-containing cells (melanocytes and melanophages) are abundant in the tumor. (c) Hematoxylin and eosin staining of the orbital tumor after using a bleaching method for melanins (×20): diffuse proliferation of the epithelioid cells and spindle cells, and low-grade nuclear atypia were seen. Small nucleoli were seen in some areas of the tissue. (d) HMB (Human Melanoma Black)-45 staining (×20): positive for atypical cells. (e) Melan-A staining (×20): positive for atypical cells. (f) Hematoxylin and eosin staining of the orbital tumor after using a bleaching method for melanins (×20): vast areas of necrosis were seen.