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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Jan 9;1840(6):1993–2003. doi: 10.1016/j.bbagen.2014.01.007

Figure 5.

Figure 5

Graphic diagram of GAG core tetrasaccharide biosynthesis and HS chain polymerization. The Ser/Thr-containing polypeptide core protein is glycosylated and modified through ten enzymatic reactions occurring in the endoplasmic reticulum and Golgi. Numbered steps correspond to the reactions catalyzed by enzymes encoded by the following genes (1): XYLT1, XYLT2, (2): B4GALT7, (3): B3GALT6, (4): B3GALT3, (5): EXTL2, EXTL3, (6): EXT1, EXT2, (7): EXT1, EXT2, EXTL1, EXTL3. (8): CSGALNACT1, CSGALNACT2, (9): CHSY1, CHPF1, CHSY3, CHPF2, and (10): DSE1, DSE2.