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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Jan 9;1840(6):1993–2003. doi: 10.1016/j.bbagen.2014.01.007

Figure 6.

Figure 6

Graphic diagram of the modification of the repeating units in the HS/HP chain. Numbers on steps correspond to the reactions catalyzed by enzymes encoded by the following genes (1): NDST1, NDST2, NDST3, NDST4, (2): GLCE, (3): HST2T1, (4): HS6ST1, HS6ST2, HS6ST3, and (5): HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST4, HS3ST5, HS3ST6. While the initial, unsulfated substrate is believed to be modified by enzymes 1–5, in that order, the figure includes all other permutations that are possible to achieve the final product, HP/HS.