TABLE 2.

Results of Platelet Functional Testing in Acute Coronary Syndrome Patients With Depressive Symptoms (PHQ-9 ≥ 10) and Without Depressive Symptoms (PHQ-9 < 10)

	PHQ-9 < 10 (n = 15)	PHQ-9 ≥ 10 (n = 7)	p
Inflammatory markers
TNF-α (pg/mL)	4.9 (1.0, 12.2) (n = 15)	3.3 (2.3, 16.7) (n = 7)	0.97
IL-6 (pg/mL)	10.0 (1.4, 108.9) (n = 15)	10.3 (1.8, 111.6) (n = 7)	0.92
hs-CRP (ng/mL)	3077.5 (463.5, 16,406.5) (n = 15)	10,459.0 (559.4, 30,000.0) (n = 7)	0.19
Functional test	n = 20	n = 8
ADP EC50 μM	6.94 (1.39, 16.21) (n = 17)	1.87 (1.25, 3.73) (n = 7)	0.004
ADP EC50 μM*	3.55 (2.35–6.94) (n = 6)	1.87 (1.25, 3.73) (n = 7)	0.046
30 μmol 5HT Percentage aggregation (amplitude)	14 (4, 28) (n = 16)	17 (0, 24) (n = 7)	0.87
3 μmol 5HT Percentage aggregation (amplitude)	11 (0, 24) (n = 15)	14 (0, 28) (n = 5)	0.97
0.3 μmol 5HT Percentage aggregation (amplitude)	5 (1, 17) (n = 14)	10 (2, 16) (n = 5)	0.23
PMP	13.56 (0.65, 49.07) (n = 18)	3.87 (0.65, 93.62) (n = 6)	0.13

ADP = adenosine diphosphate; hs-CRP = high-sensitivity C-reactive protein; IL = interleukin; PHQ = patient health questionnaire; PMP = platelet microparticles; TNF = tumor necrosis factor. Adenosine Diphosphate (ADP) EC50 – concentration of ADP needed to obtain 50% maximal aggregation (μM). Serotonin (5HT). Data presented as Median [Min, Max]. N=number. Platelet-derived microparticles (PMP).

^*Denotes comparison of patients not on Clopidogrel.

Bold values ar those p values that were significant those p values that were significant