TABLE 1.
. Select neurochemical markers expressed in the cornea*
| Nerve fiber type | Associated markers |
|---|---|
|
| |
| Somatosensory (mechanical) | NF-200165 |
|
| |
| Somatosensory (nociceptive) | |
|
| |
| Peptidergic | CGRP |
| SP | |
| PACAP | |
| Galanin | |
| 156 | |
| Non-peptidergic | FRAP |
| 156 | |
|
| |
| Autonomic | |
|
| |
| Sympathetic | NE |
| 5-HT | |
| NPY | |
| 156 | |
| Parasympathetic | ACh |
| VIP | |
| NPY | |
| Galanin | |
| 156 | |
NF-200 = neurofilament-200 kDa; CGRP = calcitonin gene-related peptide; SP = substance P; PACAP = pituitary adenylate cyclase-activating peptide; FRAP = fluoride-resistant acid phosphatase; NE = norepinephrine; 5-HT = serotonin; NPY = neuropeptide Y; ACh = acetylcholine; VIP = vasoactive intestinal peptide.
In addition to these markers, the cornea contains neuropeptides of unspecified origin. These include cholecystokinin (CCK), neurotensin, brain natriuretic peptide (BNP), vasopressin, and β-endorphin. 156
*
Based on information obtained from human and animal models.