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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: Mitochondrion. 2013 Oct 29;16:55–64. doi: 10.1016/j.mito.2013.10.004

Figure 6.

Figure 6

Proposed mechanisms for the role of DRP1 in mitochondrial fusion in response to NaBt treatment of CRC cells. (A) High expression of DRP1 during G2-M transition and its activation through cyclin B1-CDK1 complex ensures mitochondrial fission during cell division. (B) NaBt inhibits G2-M phase progression and formation of active cyclin B1-CDK1 complex and thereby inhibits the activation/phosphorylation of DRP1 and its translocation to mitochondrial membrane, on the other hand NaBt also decreased DRP1 level via inhibition of caspase activation. The combined effects for lowering the DRP1 level by NaBt would lead to mitochondrial fusion and subsequently respiratory distress and apoptosis in CRC cells.