Table 2.

Oral Mouse MES ED₅₀ Data for Selected Compounds^a

cmpd	ED50 (mg/kg, po)	95% CI	neurotoxicityb
4	120c	--	d
(S)-5	199	183–222	0/8 (250)
10a	124	85–173	6/8 (300)
10b	104	91–128	0/8 (150)
10d	230	171–281	2/8 (350)
10e	161	138–192	3/8 (300)
10h	296	202–473	3/8 (600)
11a	131	120–141	1/8 (150)
12	267	232–299	4/8 (300)
3	119c	112–126	d
phenytoin	9.0e		TD50 = 86.7e
1	43.8f		TD50 = 389g

^aMaximal electroshock seizure model, at 1 h post dosing, performed at NeuroAdjuvants. CI, 95% confidence interval.

^bMouse rotorod toxicity, at the dose in mg/kg given in parentheses. The effect is presented as the number of animals responding out of the total number of animals tested.

^cPerformed in house; result at 3 h post dosing (time of peak effect).

^dSee text for rat data.

^eAt 2 h; ref 3a.

^fAt 1 h; ref 6.

^gAt 1 h; ref 3a.