Table 1.
Integrative Model Performance
| TPR, % | AUROC | |
|---|---|---|
| Generalized linear regression (Gaussian) | 65 | 0.8261 |
| Generalized linear regression (binomial) | 65 | 0.8364 |
| Elastic-net (Gaussian) | 62 | 0.8107 |
| Elastic-Net (binomial) | 65 | 0.8331 |
| RandomForest | 52 | 0.7491 |
| Support vector machine | 44 | 0.6602 |
AUROCs for different integrative models are shown. The TRP is reported at a 15% FPR. The top performing model, generalized linear regression with a binomial link function, was designated as the EPSLiM model. A 15% FPR and 65% TPR for the EPSLiM predictor corresponds to a threshold of 0.02.