Fig. 5.
(A–C) Time course plots showing the change in BOLD signal intensity in (A) motor cortex, (B) nucleus accumbens and (C) dorsal raphe nucleus following i.v. administration of saline or fenfluramine (10 mg/kg). In two groups animals were pre-treated with the selective 5-HT2A receptor antagonist MDL100907 (0.5 mg/kg i.p.) 15 min prior to i.v. fenfluramine (MDL-fen) or vehicle (MDL-veh) injection. Data represent mean ± SEM (n = 5 per group). Fenfluramine or vehicle was administered i.v. at t = 15 min on the time course plots (arrow; MDL100907 was administered at t = 0 min relative to these plots). (D–F) Bar graphs showing mean ± SEM of the signal intensity over the first 30 min after fenfluramine or saline administration. *p < 0.05, ***p < 0.0001 (with respect to Veh-Veh); ++p < 0.01, +++p < 0.0001 (with respect to MDL-Veh); ###p < 0.0001 (with respect to MDL-Fen).