Table 1.

Occurrence of induced and spontaneous seizures in Has mutant mice

	Induced by handlinga		Spontaneous (video + EEG recorded)b
	WT	Has1−/−; Has3−/−	WT	Has1−/−	Has2CKO	Has3−/−
Total mice tested	29	40	10	7	8	9
Mice with seizures (no.)	0	19	0	1	2	5
Mice with seizures (%)	0	47.5	0	14.3	25.0	55.6

^aSeizures were induced using the HISS test (Todorova et al., 1999) and video-recorded. Mice were diagnosed to be seizure-susceptible when they exhibited behaviors ranging from immobility followed by head clonus to tonic-clonic behavior.

^bSpontaneous epileptic seizures were detected by simultaneous video-EEG recording. Mice were diagnosed as epileptic when they exhibited during 24 h recording session at least one abnormal EEG episode that lasted at least 5 s and was accompanied by behavioral seizures.