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. 2014 Apr 30;34(18):6201–6213. doi: 10.1523/JNEUROSCI.3178-13.2014

Figure 2.

Figure 2.

Ghrelin modulation of GABAergic sPSCs in VP neurons. A, Time course of mean normalized frequencies of glutamatergic sPSCs recorded in the presence of the GABAA receptor antagonist bicuculline or picrotoxin in PVN VP neurons from ad libitum fed (n = 9) and 24 h-fasted rats (n = 7). Ghrelin (100 nm) had no significant effect on the frequency of glutamatergic sPSCs. B, Summary of mean normalized glutamatergic sPSC frequency response to ghrelin (100 nm) in the presence of GABAA receptor antagonists in VP neurons from ad libitum fed and fasted rats. C, Time course of mean normalized frequency of GABAergic sPSCs recorded in the presence of the glutamate receptor antagonists DNQX and AP-5 in PVN VP neurons from ad libitum fed and fasted rats. Ghrelin (100 nm) caused an increase in the frequency of GABAergic sPSCs in VP cells from fasted, but not fed, rats. D, Summary of mean normalized GABA sPSC frequency response to ghrelin (100 nm) in the presence of glutamate receptor antagonists in VP neurons from ad libitum fed and fasted rats. **p < 0.01.