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. 2014 Apr 30;34(18):6201–6213. doi: 10.1523/JNEUROSCI.3178-13.2014

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Copyright © 2014 the authors 0270-6474/14/346201-13$15.00/0

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Figure 7. — Ghrelin elicited an increase in spiking in VP cells. A, Spiking activity in a VP neuron from a 24 h-fasted rat recorded extracellularly with the loose-seal cell-attached patch technique. Ghrelin (100 nm) elicited an increase in spiking. B, Distribution plot of changes in spike frequency in individual cells before (Control) and during ghrelin application (Ghrelin) (n = 12). C, Summary of mean normalized spike frequency responses to ghrelin in PVN VP neurons from ad libitum fed and 24 h-fasted rats. D, Summary of mean spike frequency responses to ghrelin in VP cells from fasted rats in the absence (n = 14) and presence of the GABA_A receptor antagonist bicuculline (n = 12). Blocking GABA_A receptors decreased the basal spike frequency and blocked the ghrelin-induced increase in spike frequency. *p < 0.05. n.s., Not significant.