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. 2014 Apr 30;34(18):6352–6366. doi: 10.1523/JNEUROSCI.3673-13.2014

Figure 5.

Figure 5.

Cdk5 cKO mice exhibited anxiety- and depressive-like behaviors. Control and Cdk5 cKO mice were subjected to various and repeated unpredictable mild stressors for a period of 1 week (sub-CUS) or 5 weeks (CUS) or were not subjected to any stressors (nonstressed). A, In the OFT neither stress nor Cdk5 cKO altered the total distance traveled (p > 0.05) or center time (p > 0.05). B, In nonstressed groups, Cdk5 cKO mice showed significant decrease in the SPT compared with wild-type control mice (**p < 0.01). In sub-CUS groups, Cdk5 cKO mice exhibited significant decrease in the SPT compared with control mice (***p < 0.001). In the CUS groups, Cdk5 cKO mice showed significant decrease in the sucrose preference compared with wild-type control mice (**p < 0.01). CUS (***p < 0.001), but not sub-CUS (p > 0.05), significantly decreased sucrose preference in wild-type control mice. However, both sub-CUS (***p < 0.001) and CUS (***p < 0.001) further decreased sucrose preference in Cdk5 cKO mice. C, In the EPM test, CUS, but not sub-CUS, significantly decreased the number of entries in the open arms (nonstress vs CUS, ***p < 0.001; sub-CUS vs CUS, **p < 0.01) and the time spent in the open arms (nonstress vs CUS, *p < 0.05; sub-CUS vs CUS, *p < 0.05). However, Cdk5 cKO had no significant effects on the number of entries into the open arms (p > 0.05) and the time spent in the open arms (p > 0.05). D, In nonstressed groups, Cdk5 cKO mice showed a significant increase in the latency to feed in the novel environment compared with wild-type control mice (*p < 0.05). In the sub-CUS groups, Cdk5 cKO mice also showed significant increase in the latency to feed compared with control mice (**p < 0.01), whereas CUS significantly increased the latency to feed in control mice (**p < 0.01), but did not produce further increases in the latency to feed in Cdk5 cKO mice (p > 0.05) in the NSF test. Neither stress (p > 0.05) nor Cdk5 cKO (p > 0.05) affected the latency to feed in the home cage. E, In nonstressed groups, Cdk5 cKO mice showed significant increase in the immobility time compared with wild-type control mice (*p < 0.05). In the sub-CUS groups, Cdk5 cKO mice also showed significant increases in immobility time compared with control mice (**p < 0.01), whereas CUS significantly increased immobility time in control mice (*p < 0.05) but did not produce further increases in immobility time in Cdk5 cKO mice (p > 0.05). The p values for Tukey's post hoc test results are shown on the top (*p < 0.05, **p < 0.01; ***p < 0.001; n = 10–12 mice/group).