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The DREADD receptor rM3D-Gs was expressed in midbrain dopamine neurons in the Cdk5 cKO (DAT-Cre+/−/Cdk5loxP/loxP) mice. A, Immunofluorescence labeling for AAV8-hSyn-DIO-rM3D-Gs-mCherry (red) and TH (green) in the midbrain VTA sections. Scale bar, 100 μm. B, High-power view of AAV8-hSyn-DIO-rM3D-Gs-mCherry and TH staining in the dashed boxes shown in A. AAVs were expressed in ∼85% of VTA dopamine neurons in the VTA. Scale bar, 50 μm. n = 3 mice/group.
