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. 2014 Apr 30;34(18):6405–6412. doi: 10.1523/JNEUROSCI.5302-13.2014

Figure 3.

Figure 3.

Loss of FMRP affects spine morphology at the nanoscale in an age and brain region-specific manner. A, E, I, M, Dendritic segments from CA1 and L5 pyramidal cells from wildtype and Fmr1KO mice at P14 (A, I) and P37 (E, M) show age and brain region-specific spine morphology changes. B, At P14, the cumulative frequency distributions of spine head widths in CA1 significantly differ between genotypes (Kolmogorov–Smirnov test: p = 0.007). C, D, No differences are observed for spine neck lengths (C) and widths (D). F–H, At P37, the distribution profiles of spine head widths (F), neck lengths (G), and neck widths (H) in CA1 are all significantly different between genotypes (Kolmogorov–Smirnov test: for head width, p = 0.03; for neck length, p = 0.02; for neck width, p = 0.04). J–P, For L5 cells, only the distribution profile of spine neck widths is significantly different at P14 (L; Kolmogorov–Smirnov test: P value = 0.004) between genotypes (J–P). Here, whether the P value is considered significant or not is corrected for using the false discovery rate method, which controls false positives during multiple comparisons. Shaded areas show the interanimal variability. Scale bar, 1 μm. *p < 0.05; **p < 0.01.