Methods | Randomised controlled trial. | |
Participants | 161 women with symptoms of nausea with or without vomiting and retching during pregnancy. Gestational age for most (78.6%) women was < 12 weeks, maximum gestation 24 weeks (not stated for how many) | |
Interventions | P6 (Neiguan) acupressure group - band applied for 5 days, removed morning of day 6 Placebo acupressure group (acupressure band inappropriately placed) Control group - no treatment. 7-day study. |
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Outcomes | Symptoms of nausea and vomiting, using Rhodes Inventory of Nausea and Vomiting (Form 2), measuring prevalence and amount of distress caused by symptoms over 12 hour period, recorded twice daily from entry to the study to 6 days later | |
Notes | Gestation up to 23.6 weeks; no raw usable data provided. | |
Risk of bias | ||
Item | Authors’ judgement | Description |
Adequate sequence generation? | Yes | Use of a process of block randomisation (size of blocks not specified), computer generated |
Allocation concealment? | Yes | The blocks of group assignments were computer generated and placed in numbered sealed envelopes before the study began. Participants were given numbers that corresponded with their envelope numbers and this was determined by the order in which they entered the study |
Blinding? Change in grade of nausea or vomiting at second visit compared to first |
Yes | Only participants randomised to the control group were aware of their group assignment |
Incomplete outcome data addressed? Change in grade of nausea or vomiting at second visit compared to first |
Yes | 12 participants withdrew at various times during the study (5 lost of interest in evaluating their symptoms during the study, 3 for disappointment at being assigned to control group, 2 were hospitalised for severe symptoms and 4 refused to discontinue the intervention at the appropriate time) |
Free of selective reporting? | Unclear | Results reported graphically only, as mean squares. |
Free of other bias? | Yes |