Study	Reason for exclusion
Baum 1963	Quasi-randomised, alternate allocation of patients to groups
Bayreuther 1994	Crossover design.
Can Gurkan 2008	Planned as a randomised study, but not carried out as planned (patients on each day placed in same group)
Cartwright 1951	Crossover design.
Conklin 1958	Not randomised, patients “arbitrarily allocated” to groups.
De Aloysio 1992	Crossover design.
Diggory 1962	Quasi-randomised “each patient in sequence was allocated”; control group reallocated if not improving
Dundee 1988	Not an RCT; women allocated to groups by day of the week; non-responders replaced in treatment group
Evans 1993	Crossover design.
Ferruti 1982	This is a study of hypocorticalism in pregnancy.
Fitzgerald 1955	Not an RCT; alternate allocation of patients.
Heazell 2006	Severe symptoms, in-patient; hyperemesis gravidarum implied (severe symptoms plus ketonuria)
Higgins 2009	Hyperemesis gravidarum (day care versus in-patient management; trial registry record only, no data)
Hyde 1989	Crossover design.
Kadan 2009	Hyperemesis gravidarum as specified condition of participants (RCT, with crossover if first drug allocated not effective: thiamine 100mg IV or promethazine 25mg IV; started February 2009, trial registry record only, ongoing at May 2010)
King 1955	Type of crossover design.
Koren 2006	Pre-emptive treatment; not treating symptoms.
Lask 1953	Not an RCT.
Luz 1987	No data available; this is a communication of a planned trial - a search identified no further publications from this study
Steele 2001	Quasi-experimental design posttest-only and post-test repeated measure
Wheatley 1977	Crossover design.
Winters 1961	Quasi randomised trial - “test material and placebo were strictly alternated”

IV: intravenous

RCT: randomised controlled trial