Methods	Within a series of studies; a double-blind comparative experiment, a controlled double blind study
Participants	100 ward (not explained) and private patients.
Interventions	Bendectin (10 mg each of Bentyl, Decapryn and Pyridoxine), 2 tablets nightly, an additional tablet in the morning as required Placebo (not described).
Outcomes	Relief from nausea and vomiting: complete, partial or no relief No description of how or when outcomes were measured.
Notes
Risk of bias
Item	Authors’ judgement	Description
Adequate sequence generation?	Unclear	No description about randomisation.
Allocation concealment?	Unclear	No description about allocation concealment; tablets were in envelopes with an identification number
Blinding? Change in grade of nausea or vomiting at second visit compared to first	Yes	Neither the physician nor the patient was aware of the identity of the tablet administered
Incomplete outcome data addressed? Change in grade of nausea or vomiting at second visit compared to first	Yes	1 patient in treatment group received medication for 1 day, otherwise all patients’ outcomes reported in results
Free of selective reporting?	Yes	Outcomes reported.
Free of other bias?	Unclear	2 patients were included in both the treatment and control groups as they received medication on 2 separate occasions during the study Not stated how or when outcomes were recorded.