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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: Immunity. 2014 Mar 20;40(3):315–327. doi: 10.1016/j.immuni.2014.02.009

Figure 3. SPM Actions and Target Cell Type.

Figure 3

The defining actions of SPM in the innate response of interest in immunology. The actions to stimulate termination and resolution. The precursors essential polyunsaturated fatty acids (AA, EPA, DHA) are converted by leukocytes to separate chemically distinct families of mediators that stimulate active resolution responses of isolated cell types and tissues in vivo in animal models. Some of the specific target cell types and representative potent actions of the SPM members from each family of related structures are listed. All of these actions of SPMs are stereoselective and in the picogram-nanogram range potency. See Serhan and Chiang (2013) and text for further details.