Table 1.
Power of DNA pooling strategy compared to individual genotyping
| OR | Functional SNP (%) |
Individual genotyping (%) |
DNA pooling (%) |
|---|---|---|---|
| 5% threshold | |||
| 1.2 | 0 | 0 | 0 |
| 1.3 | 6 | 4 | 3 |
| 1.5 | 51 | 41 | 31 |
| 1.7 | 80 | 68 | 56 |
| 2 | 93 | 82 | 72 |
| 3 | 99 | 90 | 85 |
| Log P >3 | |||
| 1.2 | 19 | 19 | 4 |
| 1.3 | 53 | 49 | 16 |
| 1.5 | 88 | 80 | 47 |
| 1.7 | 97 | 90 | 66 |
| 2 | 99 | 92 | 76 |
| 3 | 100 | 95 | 87 |
Abbreviations: OR, odds ratio; SNP, single-nucleotide polymorphism; 5% threshold, power to detect the association with significance above the 5% genome-wide threshold; log P > 3, percentage of cases with log P > 3, in a design that includes testing the log P > 3 SNPs in a replication sample.