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. 2014 Mar 25;2014:928461. doi: 10.1155/2014/928461

Figure 3.

Figure 3

Th1/Th17 balance. Th17 cells exhibit plasticity towards the Th1 phenotype: Th17/Th1 cells or Th17-driven Th1 cells are cells capable of producing both IL-17 and IFN-γ. Th1 cells that derive from Th17 cells can be identified by the expression of CD161, a signature surface marker of Th17 cells progenitors, as opposed to classic CD161− Th1 cells. TGFβ is required for sustained expression of IL-17F and IL-17A, but in the absence of TGFβ, both IL-23 and IL-12 downregulate RORγt and upregulate T-bet expression, which may result in the suppression of IL-17 and enhancement of IFN-γ production, in a STAT4- and T-bet-dependent manner.