Table 1.

Characteristics of Novamin containing toothpastes excluded studies.

Number	Study	Reason
1	Bakry et al. [11]	In vitro investigation
2	Burwell et al. [12]	In vitro investigation
3	Burwell et al. [13]	In vitro investigation
4	Chiang et al. [14]	In vitro investigation
5	Earl et al. [15]	In vitro investigation
6	Farmakis et al. [16]	In vitro investigation
7	Gillam et al. [17]	In vitro investigation
8	Gjorgievska and Nicholson [18]	In vitro investigation
9	Golpayegani et al. [19]	In vitro investigation
10	Mitchell et al. [20]	In vitro investigation
11	Mneimne et al. [21]	In vitro investigation
12	Parkinson et al. [22]	Abstract only (at the time of collection of papers). However as the study lacked a negative control in the clinical trial design methodology it was excluded from the present review
13	Sauro et al. [23]	In vitro investigation
14	Wang et al. [24]	In vitro investigation
15	Wang et al. [25]	In vitro investigation
16	Greenspan [26]	Review
17	Du et al. [27]	No mention of randomisation and allocation concealment methods
18	Patsouri et al. [28]	Abstract only
19	Surve et al. [29]	Abstract only (at the time of collection of papers). However the study investigated the combination of an In-office application with or without a OTC desensitizing toothpaste following periodontal treatment and was therefore considered irrelevant for the present review
20	Yu et al. [30]	Publication in Chinese (Abstract in English)
21	Milleman et al. [31]	In-office agent (professionally applied polishing paste) and not as an OTC desensitizing toothpaste
22	Narongdej et al. [32]	Novamin used as in-office agent
23	Banerjee et al. [33]	Study duration ≤10 days
24	Tai et al. [37]	Investigated the antigingivitis effect of Novamin on the gingival tissues (desensitizing toothpaste per se) and therefore the study was considered irrelevant to this review
25	Acharya et al. [34]	Excluded as the publication date was after December 31st and lacked a negative control in the clinical trial design methodology
26	Ananthakrishna et al. [35]	Excluded as the publication date was after December 31st and lacked a negative control in the clinical trial design methodology
27	Neuhaus et al. [36]	Excluded as the publication date was after December 31st and evaluated an In-office agent (professionally applied polishing paste)
28	Salian et al. [38]	The negative control group contained fluoride whereas the test group (Novamin) did not
29	Sharma et al. [39]	The negative control group contained fluoride whereas the test group (Novamin) did not
30	West et al. [40]	The dentine specimens were placed in intraoral appliances worn by patients to establish an in situ effect of Novamin
31	Rajesh et al. [41]	One further study was excluded due to the lack of description on the composition of the control randomization