Table 5.

Characteristics of Novamin containing toothpastes included studies.

Number	Studies	Methods	Participants	Interventions	Outcomes	Results
1	Pradeep et al. [64]	6-week triple-blinded RCT	149 completing out of 160	Group A: 5% potassium nitrate toothpaste -Group B: 5% calcium sodium phosphosilicate toothpaste -Group C: 3.85% amine fluoride toothpaste -Group D: placebo toothpaste (negative control; no information was provided as to the constituents of control)	Pre-op and post-op evaporative (controlled air stimulus) and thermal stimuli (10 mL of ice cold water) used	5% CSPS > 3.85% amine fluoride > KNO3 > placebo
2	Pradeep and Sharma [65]	6-week triple-blinded RCT	110 completing out of 120	Group A: 5% calcium sodium phosphosilicate (Novamin) toothpaste -Group B: 5% potassium nitrate toothpaste (positive control) -Group C: same formulation as toothpaste A; however, no active ingredient (negative control)	Pre-op and post-op evaporative (controlled air stimulus) and thermal stimuli (10 mL of ice cold water) used	5% CPS > KNO3 > placebo
3	Litkowski and Greenspan [66]	8-week double-blind randomized placebo controlled pilot study	66 No mention of dropouts	Group A: placebo control toothpaste (negative control; no information was provided as to the constituents of control) -Group B: 2.5% Novamin toothpaste -Group C: 7.5% Novamin toothpaste	Pre-op and post-op tactile (Yeaple probe calibrated at 40 g force) and an evaporative stimulus (one-second air blast)	7.5% CSPS > 2.5% CSPS > placebo