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Drug Candidates with Possible Neuroprotective Effects
| Drug Candidate | Pathways Inhibited | IC50 -T channel | Neuroprotection |
|---|---|---|---|
| A1048400 | T-Type and N-Type | 1.2-4.6μM | ? |
| KYS05044 | T-Type (CaV3.1, CaV3.2) | 1μM | ? |
| ML218 | T-Type (CaV3.1-CaV3.3) | 150-310nM | Y |
| NNC 55-0396 | T-Type | 7μM | Y |
| RQ-00311610 | T-Type | 110-170nM | ? |
| TTA-A2 | T-Type (CaV3.1-3.3) | 50-100nM | Y |
| TTA-P2 | T-Type | 22nM | ? |
| VH04 | T-Type (CaV3.1) | 100nM | ? |
| Z941/944 | T-Type | 50-160nM | Y |
