Table 1.
Frequency of antibodies to eight TAAs.
| Autoantibodies to | Number (%) of autoantibodies in different types of cancers | ||||||
|---|---|---|---|---|---|---|---|
| Lung (98) | HCC (50) | Colorectal (46) | Gastric (41) | Others (69) | Total (304) | NHS (58) | |
| Koc | 9 (9.2)a | 9 (18.0)b | 7 (15.2)b | 2 (4.9) | 8 (11.6)a | 35 (11.5)b | 0 |
| p62 | 15 (15.3)b | 10 (20.0)b | 10 (21.7)b | 4 (9.8) | 9 (13.0)a | 48 (15.8)b | 1 (1.7) |
| Imp1 | 17 (17.3)b | 8 (16.0)b | 10 (21.7)b | 6 (14.6)b | 9 (13.0)a | 50 (16.4)b | 0 |
| Cyclin B1 | 17 (17.3)b | 10 (20.0)b | 8 (17.4)a | 11 (26.8)b | 12 (17.4)b | 58 (19.1)b | 1 (1.7) |
| p16 | 18 (18.4)b | 3 (6.0) | 9 (19.6)a | 4 (9.8) | 13 (18.8)b | 47 (15.5)a | 2 (3.4) |
| Survivin | 19 (19.4)b | 6 (12.0) | 7 (15.2)a | 6 (14.6)a | 10 (14.5)a | 48 (15.5)b | 1 (1.7) |
| C-myc | 24 (24.5)b | 7 (14.0) | 10 (21.7)b | 7 (17.1)a | 17 (24.6)b | 65 (21.4)b | 2 (3.4) |
| p53 | 25 (25.5)b | 10 (20.0)a | 11 (23.9)b | 5 (12.2) | 14 (20.3)b | 65 (21.4)b | 2 (3.4) |
| Cumulative to eight antigens | 63 (64.3)b | 33 (66.0)b | 30 (65.2)b | 23 (56.1)b | 44 (63.8)b | 193 (63.5)b | 8 (13.8) |
Cutoff value: mean +2 SD of NHS; P values to NHS were calculated to be <0.05 (a) or 0.01 (b).
HCC: hepatocellular carcinoma; NHS: normal human sera.