Table 3.
Evaluation of diagnostic values of different TAA panels in the diagnosis of cancer.
| Number of different TAA panelsa | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | ||
| NHS | Positive % (number) | 0 (0) | 1.7 (1) | 1.7 (1) | 3.4 (2) | 6.9 (4) | 8.6 (5) | 12.1 (7) | 13.8 (8) |
|
| |||||||||
| Lung (98) | Positive % (number) | 9.2 (9) | 20.4 (20) | 31.6 (31) | 41.8 (41) | 48.0 (47) | 55.1 (54) | 59.2 (58) | 64.3 (63) |
| Se/Sp | 9.2/100.0 | 20.4/98.3 | 31.6/98.3 | 41.8/96.6 | 48.0/93.1 | 55.1/91.4 | 59.2/87.9 | 64.3/86.2 | |
| YI | 0.092 | 0.187 | 0.299 | 0.384 | 0.411 | 0.465 | 0.471 | 0.505 | |
| PPV/NPV | 100.0/39.5 | 95.2/42.2 | 96.9/46.0 | 95.3/49.6 | 92.2/51.4 | 91.5/54.6 | 89.2/56.0 | 88.7/58.8 | |
|
| |||||||||
| HCC (50) | Positive % (number) | 18.0 (9) | 34.0 (17) | 44.0 (22) | 52.0 (26) | 54.0 (27) | 58.0 (29) | 64.0 (32) | 66.0 (33) |
| Se/Sp | 18.0/100.0 | 34.0/98.3 | 44.0/98.3 | 52.0/96.6 | 54.0/93.1 | 58.0/91.4 | 64.0/87.9 | 66.0/86.2 | |
| YI | 0.180 | 0.323 | 0.423 | 0.486 | 0.471 | 0.494 | 0.520 | 0.522 | |
| PPV/NPV | 100.0/58.6 | 94.4/63.3 | 95.7/67.1 | 92.9/70.0 | 87.1/70.1 | 85.3/71.6 | 82.1/73.9 | 80.5/74.6 | |
|
| |||||||||
| Colorectal (46) | Positive % (number) | 15.2 (7) | 32.6 (15) | 43.5 (20) | 47.8 (22) | 52.2 (24) | 54.3 (25) | 60.9 (28) | 65.2 (30) |
| Se/Sp | 15.2/100.0 | 32.6/98.3 | 43.5/98.3 | 47.8/96.6 | 52.2/93.1 | 54.3/91.4 | 60.9/87.9 | 65.2/86.2 | |
| YI | 0.152 | 0.309 | 0.418 | 0.444 | 0.453 | 0.457 | 0.488 | 0.514 | |
| PPV/NPV | 100.0/59.8 | 93.8/63.3 | 95.2/68.7 | 91.7/70.0 | 85.7/71.1 | 83.3/71.6 | 80.0/73.9 | 78.9/75.8 | |
|
| |||||||||
| Gastric (41) | Positive % (number) | 4.9 (2) | 14.6 (6) | 24.4 (10) | 39.0 (16) | 46.3 (19) | 51.2 (21) | 56.1 (23) | 56.1 (23) |
| Se/Sp | 4.9/100.0 | 14.6/98.3 | 24.4/98.3 | 39.0/96.6 | 46.3/93.1 | 51.2/91.4 | 56.1/87.9 | 56.1/86.2 | |
| YI | 0.049 | 0.129 | 0.227 | 0.356 | 0.394 | 0.426 | 0.440 | 0.423 | |
| PPV/NPV | 100.0/59.8 | 85.7/62.0 | 90.9/64.8 | 88.9/69.1 | 82.6/71.1 | 80.8/72.6 | 76.7/73.9 | 74.2/73.5 | |
|
| |||||||||
| Others (69) | Positive % (number) | 11.6 (8) | 21.7 (15) | 26.1 (18) | 42.0 (29) | 52.2 (36) | 55.1 (38) | 60.9 (42) | 63.8 (44) |
| Se/Sp | 11.6/100.0 | 21.7/98.3 | 26.1/98.3 | 42.0/96.6 | 52.2/93.1 | 55.1/91.4 | 60.9/87.9 | 63.8/86.2 | |
| YI | 0.116 | 0.200 | 0.244 | 0.386 | 0.453 | 0.465 | 0.488 | 0.500 | |
| PPV/NPV | 100.0/48.7 | 93.8/51.4 | 94.7/52.8 | 93.5/58.3 | 90.0/62.1 | 88.4/63.1 | 85.7/65.4 | 84.6/66.7 | |
|
| |||||||||
| Total (304) | Positive % (number) | 11.5 (35) | 24.0 (73) | 33.2 (101) | 44.1 (134) | 50.3 (153) | 55.0 (167) | 60.2 (183) | 63.5 (193) |
| Se/Sp | 11.5/100.0 | 24.0/98.3 | 33.2/98.3 | 44.1/96.6 | 50.3/93.1 | 55.0/91.4 | 60.2/87.9 | 63.5/86.2 | |
| YI | 0.115 | 0.223 | 0.315 | 0.407 | 0.434 | 0.464 | 0.481 | 0.497 | |
| PPV/NPV | 100.0/17.7 | 98.6/19.8 | 99.0/21.9 | 98.5/24.8 | 97.5/26.3 | 97.1/27.9 | 96.3/29.7 | 96.0/31.1 | |
aNumber of different TAA panels, corresponding to TAA panels shown in Table 2.
Se: sensitivity; Sp: specificity; YI: Youden's index; PPV: positive predictive value; NPV: negative predictive value.