Table 4.
Summary of diagnostic value of antibodies to a panel of eight TAAs.
| Lung | HCC | Colorectal | Gastric | Others | Total | NHS | |
|---|---|---|---|---|---|---|---|
| Any TAA positive | 63 (A1) | 33 (A2) | 30 (A3) | 23 (A4) | 44 (A5) | 193 (A6) | 8 (B) |
| All TAA negative | 35 (C1) | 17 (C2) | 16 (C3) | 18 (C4) | 25 (C5) | 111 (C6) | 50 (D) |
| Youden's index | 0.505 | 0.522 | 0.514 | 0.423 | 0.500 | 0.497 | — |
| +Likelihood ratio | 4.66 | 4.76 | 4.72 | 4.07 | 4.62 | 4.60 | — |
| −Likelihood ratio | 0.41 | 0.39 | 0.45 | 0.51 | 0.42 | 0.42 | — |
| +Predictive value | 88.7 | 80.5 | 78.9 | 74.2 | 84.6 | 96.0 | — |
| −Predictive value | 58.8 | 74.6 | 75.8 | 73.5 | 66.7 | 31.1 | — |
| Agreement rate | 72.4 | 76.9 | 76.9 | 73.7 | 74.0 | 67.1 | — |
| Kappa value | 0.46 | 0.53 | 0.52 | 0.44 | 0.49 | 0.51 | — |
Note: Calculation Formulas used in Table 4 were as follows.
Youden's index = sensitivity + specificity − 1.
Positive (+) likelihood ratio = sensitivity/(1 – specificity).
Negative (−) likelihood ratio = (1 – sensitivity)/specificity.
Positive (+) predictive value = A/(A + B) × 100%.
Negative (−) predictive value = D/(C + D) × 100%.
Agreement rate = (A + D)/(A + B + C + D) × 100%.
Kappa value = [N(A + D)−(R1C1 + R2C2)]/[N2 − (R1C1 + R2C2)].