Absolute |
• Histological demonstration of the parasite from biopsy of a brain or spinal cord lesion |
• Evidence of cystic lesions showing the scolex on neuroimaging studies |
• Direct visualization of subretinal parasites by fundoscopic examination |
Major |
• Evidence of lesions highly suggestive of neurocysticercosis on neuroimaging studies |
• Positive serum immunoblot for the detection of anticysticercal antibodies |
• Resolution of intracranial cystic lesions after therapy with albendazole or praziquantel |
• Spontaneous resolution of small single enhancing lesions |
Minor |
• Evidence of lesions compatible with neurocysticercosis on neuroimaging studies |
• Presence of clinical manifestations suggestive of neurocysticercosis |
• Positive CSF ELISA for detection of anticysticercal antibodies or cysticercal antigens |
• Evidence of cysticercosis outside the central nervous system |
Epidemiological |
• Individuals coming from or living in an area where cysticercosis is endemic |
• History of travel to disease-endemic areas |
• Evidence of a household contact with T. solium infection |
Degrees of diagnostic certainty |
Definitive |
• Presence of one absolute criterion |
• Presence of two major plus one minor and one epidemiological criteria |
Probable |
• Presence of one major plus two minor criteria |
• Presence of one major plus one minor and one epidemiological criteria |
• Presence of three minor plus one epidemiological criteria |