Table 1.

The Six Transformations Applied to Six Disconnected Groups of the Partition of McCray et al.¹⁶

Old Group Name	Isolated Semantic Types and/or Trees in a Disconnected Group	Transformation Type	Transformations Applied	New Group Name
Chemicals and Drugs	Clinical Drug	Split transformation	Split into two connected groups; the group Clinical Drug contains just one semantic type	Two groups: Chemical; Clinical Drug
Devices	Research Device; Medical Device	Root-moving transformation	Move Manufactured Object from the Objects group and make it the new root of the Devices group	Manufactured Object
Genes and Molecular Sequences	Gene or Genome	IS-A addition transformation	Add (Gene or Genome IS-A Molecular Sequence) link	Molecular Sequence
Living Beings	{Organism; Fungus; Alga; Virus; Human; Plant; Archaeon; Reptile; Rickettsia or Chlamydia; Amphibian; Mammal; Fish}; {Group; Family Group; Age Group; Population Group; Professional or Occupational Group; Patient or Disabled Group}	Split transformation	Split into two smaller connected groups	Two groups: Organism; Group
Phenomena	Laboratory or Test Result	IS-A addition transformation	Add (Laboratory or Test Result IS-A Phenomenon or Process) link	Phenomenon or Process
Physiology	{Organism Attribute; Clinical Attribute}	IS-A addition transformation	Add (Organism Attribute IS-A Physiologic Function) link	Physiologic Function